S
- Sabrina – The Animated Series – Spooked! (USA, Europe)
- Sabrina – The Animated Series – Zapped! (USA, Europe)
- San Francisco Rush 2049 (USA, Europe)
- Scooby-Doo! – Classic Creep Capers (USA, Europe)
- Sesame Street Sports (USA)
- Sewing Machine Operation Software (USA) (En,Fr,Es) (GB Compatible)
- Sgt. Rock – On the Frontline (USA)
- Shadowgate Classic (USA, Europe) (En,Fr,De,Es,Sv) (GB Compatible)
- Shamus (USA, Europe) (GB Compatible)
- Shanghai Pocket (USA) (SGB Enhanced) (GB Compatible)
- Shantae (USA)
- Shaun Palmer’s Pro Snowboarder (USA, Australia)
- Shrek – Fairy Tale Freakdown (USA, Europe) (En,Fr,De,Es,It)
- Simpsons, The – Night of the Living Treehouse of Horror (USA, Europe)
- Smurfs Nightmare, The (USA)
- Snoopy Tennis (USA) (En,Fr,Es)
- Snow White and the Seven Dwarfs (USA)
- Space Invaders (USA, Europe) (GB Compatible)
- Space Marauder (USA)
- Spawn (USA)
- Speedy Gonzales – Aztec Adventure (USA, Europe) (GB Compatible)
- Spider-Man (USA, Europe)
- Spider-Man 2 – The Sinister Six (USA, Europe)
- SpongeBob SquarePants – Legend of the Lost Spatula (USA, Europe)
- Spy vs. Spy (USA)
- Star Wars Episode I – Obi-Wan’s Adventures (USA)
- Star Wars Episode I – Racer (USA, Europe) (Rumble Version)
- Street Fighter Alpha – Warriors’ Dreams (USA)
- Stuart Little – The Journey Home (USA, Europe)
- Super Breakout! (USA) (GB Compatible)
- Super Mario Bros. Deluxe (USA, Europe)
- Survival Kids (USA) (SGB Enhanced) (GB Compatible)
